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Drug Repositioning: Bringing New Life to Shelved Assets and Existing Drugs, by Michael J. Barratt, Donald E. Frail
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The how's and why's of successful drug repositioning
Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy.
Drug Repositioning is divided into three parts:
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Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs.
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Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents.
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Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return.
The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits.
With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
- Sales Rank: #826392 in Books
- Published on: 2012-05-29
- Original language: English
- Number of items: 1
- Dimensions: 9.45" h x 1.20" w x 6.40" l, 1.83 pounds
- Binding: Hardcover
- 498 pages
Review
“Overall, this book is so complete that it is a must read for all the players in drug repositioning, not only �researches or drug developers, but also business development specialist, investors, venture capital firms, academia and regulators that need a compressive description that will satisfy novice and more experienced professionals.”� (ChemMedChem, 1 March 2013)
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Most helpful customer reviews
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Leveraging Pharmaceutical Research Assets: Projects With Lower Cash Requirements and Faster Time to Commercialization
By Thomas M. Loarie
"Drug Repositioning" is an excellent resource for biopharmaceutical executives and researchers who are interested in this burgeoning field. Editors Michael Barratt and Donald Frail have successfully corralled 42 experts to contribute meaningful reference papers, providing much more than a basic primer on this daunting topic. Subject areas which are presented in three parts include:
PART I - DRUG REPOSITIONING: The business case, strategies, and operational considerations.
1. Drug Repositioning - the business case and strategies to repurpose shelved candidates
2. The Opportunities and Challenges for developing new indications
3. Clinical and Operational Challenges in repositioning
4. Regulatory Considerations
PART II - APPLICATIONS
1. Computational and Bioinformatic Strategies
2. Mining Scientific and Clinical Data Bases to Identify Novel Uses
3. Predicting the Polypharmacology of Drugs
4. Systemic Phenotype Screening for Novel Synergistic Combinations
5. Phenotypic In Vivo Screening
6. Old Drugs Yield New Discoveries
PART III - ACADEMIC AND NONPROFIT INITIATIVES AND THE ROLE OF ALLIANCES IN THE DRUG REPOSTIONING INDUSTRY
1. Repurposing Drugs for Tropical Disease
2. Drug Repositioning Efforts by Nonprofit Foundations
3. Business Development Strategies
4. A Case Study - Sosei
Contributors come from industry, the academy, and non-profits including AstraZeneca, Thomas Reuters, Concert, Pfizer, Comargo, Bayer, Concert, the University of California, Washington University, The Michael J. Fox Foundation, and Polycystic Kidney Disease Foundation.
Drug repositioning, also commonly referred to as drug re-profiling or repurposing, has become an increasingly important part of the drug development process for many companies in recent years. Identifying new indications for existing drugs, discontinued, or "shelved" assets is a very practical and attractive way to leverage prior or current investments in preclinical and clinical research that were originally designed with different patient populations in mind. This has become the starting point for numerous biopharma start-ups since this approach requires significantly less development capital and accelerates the time to commercialization.
I am now involved in my second start-up commercializing a re-profiled drug or class of drugs. I have found ""Drug Repositioning" an invaluable resource and guide.
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